Radicals and the birth and death of DNA

Authors
Citation
B. Giese, Radicals and the birth and death of DNA, CHIMIA, 55(4), 2001, pp. 275-280
Citations number
23
Categorie Soggetti
Chemistry
Journal title
CHIMIA
ISSN journal
00094293 → ACNP
Volume
55
Issue
4
Year of publication
2001
Pages
275 - 280
Database
ISI
SICI code
0009-4293(2001)55:4<275:RATBAD>2.0.ZU;2-S
Abstract
Radicals have important functions in the enzymatic synthesis of deoxyribonu cleotides and their destruction by antibiotics. The chemical basis for thes e reactions is that radicals dramatically speed up ionic reactions. Nature has developed methods to generate these radicals under mild conditions in w ater as solvent. The 'catalytic' effect of these reactive intermediates is described.