The term 'proteome' describes the expressed protein complement of a genome.
The largely invariant genome of an individual or organism determines its p
otential for gene- and protein expression but does not specify which protei
ns are expressed in the various types of cells in an organism or individual
or their level or extent of post-translational modification. Furthermore,
the proteomes of cells are directly affected by environmental factors, such
as stress or drug treatment, or by aging and disease. This review briefly
describes a selection of the main technologies applied by proteome sciences
and their applications to study complex biological problems.