Plasma fibrinogen in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction

Background Authors both of retrospective and of prospective studies have de monstrated that there is a relationship between concentration of fibrinogen in plasma and the angiographically determined severity of coronary heart d isease (CHD). Objective To determine the relevance of the plasma fibrinogen concentration for the severity of CHD, particularly in cases with additional arterioscle rotic changes in the extracranial arteries supplying the brain [cerebrovasc ular disease (CVD)], in the pelvic/leg arteries [peripheral occlusive arter ial disease (POAD)], or in both. Patients and methods In a retrospective cross-sectional survey the cardiolo gical and angiographical status of a total of 1112 male and 299 female pati ents with stable angina pectoris after sustained myocardial infarction and an age-matched control group of 326 male and 138 female subjects with no cl inical symptoms of CHD was determined, together with measurements of plasma fibrinogen, dynamic plasma viscosity and D-dimers. Results More than two-thirds of the patients with arteriosclerosis had plas ma fibrinogen concentrations in the uppermost tertile of the control range (men > 2.75; women > 2.83 g/l). Plasma fibrinogen concentration was correla ted to the severity of CHD (for men r = 0.173, P < 0.001; for women r = 0,1 44, P < 0.013), Patients with generalized arteriosclerosis had higher plasm a fibrinogen concentrations than did those suffering from CHD only (for men , control 2.65 +/- 0.51, CHD 3.07 +/- 0.73, CHD plus POAD 3.17 +/- 0.77 and CHD plus POAD plus CVD 3.45 +/- 0,78 g/l; for women, control 2.69 +/- 0,44 , CHD 3.25 +/- 0,67, CHD plus POAD 3.19 +/- 0.77, CHD plus POAD plus CVD 3. 60 +/- 0.84 g/l). Multivariate analysis showed that C-reactive protein, D-d imers and dynamic plasma viscosity accounted for 48.2% (for men) and 49.4% (for women) of the variance in plasma fibrinogen concentration. Conclusions Our findings demonstrate that there is not only a correlation b etween plasma fibrinogen concentration and the severity of CHD, but also a correlation to the incidence of additional POAD or CVD. Coron Artery Dis 12 :157-165 (C) 2001 Lippincott Williams & Wilkins.