Insulin sensitivity and stress

Metabolic adaptation is part of the response to stress and participate to p roduce a favorable state for cure. Carbohydrate metabolism is profondly alt ered with an increase in basal cellular glucose uptake and utization and in endogenous glucose production;insulin sensitivity is decreased. Glucose to lerance is altered and hyperglycemia develops. This state of hyperglycemia is most obviously directed to satisfy the increased need of the injured org ans and of the inflammatory cells. The role of the cytokines in association to the stress hormones is important to these metabolic adaptations. This a rticle reviews the main features of glucose homeostasis and the potential m echanisms leading to stress induced insulin resistance.