Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus

Several pharmacological agents are associated with hyperlipidemia. Tamoxife n is an example of a drug-induced increase of serum triglyceride levels. Ho wever, there are only scarce reports on how inborn errors in lipid metaboli sm as well as secondary dyslipidemias, including diabetes mellitus, influen ce the hypertriglyceridemic effect of tamoxifen. Herein, we describe a case of a breast cancer patient receiving tamoxifen who presented with remarkab le hypertriglyceridemia in the context of diabetes mellitus. We also provid e a brief review of the relevant literature and discuss the mechanisms unde rlying the pathogenesis of hypertriglyceridemia related to tamoxifen.