USE OF MULTIVITAMIN MINERAL PRENATAL SUPPLEMENTS - INFLUENCE ON THE OUTCOME OF PREGNANCY/

The objective of this study was to examine the association of prenatal multivitamin/mineral supplement use during the first and second trime sters of pregnancy by low income, urban women in the Camden Study (198 5-1995, n = 1,430) and preterm delivery (<37 completed weeks) and infa nt low birth weight (<2,500 g). Prenatal supplement use was corroborat ed by assay of circulating micronutrients at entry to care (no differe nces) and week 28 gestation (increased concentrations of folate and fe rritin for supplement users). Compared with women who entered care dur ing the first or second trimester but did not use prenatal supplements , supplement use starting in the first or second trimester was associa ted with approximately a twofold reduction in risk of preterm delivery . After controlling for potential confounding variables, risk of very preterm delivery (<33 weeks' gestation) was reduced more than fourfold for first trimester users and approximately twofold when use dated fr om the second trimester. Infant low birth weight and very low birth we ight (<1,500 g) risks were also reduced. Risk of low birth weight was reduced approximately twofold with supplement use during the first and second trimester. Diminution in risk was greater for very low birth w eight infants, amounting to a sevenfold reduction in risk of very low birth weight with first trimester supplementation and a greater than s ixfold reduction when supplement use started in the second trimester. Thus, in low income, urban women, use of prenatal multivitamin/mineral supplements may have the potential to diminish infant morbidity and m ortality.