The influence of tibolone upon serum leptin levels in post-menopausal women

Citation
Dk. Panidis et al., The influence of tibolone upon serum leptin levels in post-menopausal women, EUR J OB GY, 96(1), 2001, pp. 85-87
Citations number
16
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
03012115 → ACNP
Volume
96
Issue
1
Year of publication
2001
Pages
85 - 87
Database
ISI
SICI code
0301-2115(200105)96:1<85:TIOTUS>2.0.ZU;2-T
Abstract
Objective: To estimate serum leptin levels in post-menopausal women, to rel ate these to the duration of the post-menopausal period, and to body mass i ndex (BMI), and to assess the influence of tibolone on them. Methods: Fifte en women (age 49-64 years) were included. Three groups were studied: I, tho se with normal BMI taking tibolone; II, those with a raised BMI taking tibo lone. and III, a group with raised BMI not laking tibolone. Blood samples w ere drawn before and 1, 2, 6, 9 and 12 months after the initiation of tibol one or, in group III, after the start of the study. Results: Serum leptin c oncentrations were high in all women with abnormal BMI, Long-term tibolone administration did not have any significant effect on serum leptin concentr ations. There was no correlation between serum leptin levels and the age an d the duration of post-menopausal period. There was a high positive correla tion between serum leptin levels and BMI values. Conclusions: BMI values af fect serum leptin concentrations but long-term tibolone administration does not seem to have any effect on serum leptin levels. (C) 2001 Elsevier Scie nce Ireland Ltd. All rights reserved.