The presence and extent of endometriosis do not effect clinical pregnancy and implantation rates in patients undergoing intracytoplasmic sperm injection

Objective: To assess the impact of endometriosis on the outcome of intracyt oplasmic sperm injection (ICSI) outcome. Study Design: Retrospective case-c ontrol study which enrolled 1280 consecutive cycles of 834 couples of ICSI with ejaculated sperm. Among them, 973 cycles of 632 couples had resulted i n embryo transfer (ET). The presence of endometriosis was noted in 110 cons ecutive cycles of 45 patients among which 78 cycles of 44 patients had resu lted in ET. Data from endometriosis group were analyzed in subgroups of min imal-mild (49 ET cycles of 25 patients) and moderate-severe (29 ET cycles o f 19 patients). The controls consisted of 1170 consecutive cycles of age ma tched 771 couples. Of. the controls. 588 couples had 895 cycles of ET. Main outcome measures were implantation and clinical pregnancy rates. Result: T here were no differences in cycle and ET cancellation rates between control and endometriosis groups. The number of oocytes retrieved, fertilization a nd cleavage rates and the number and quality of embryos developed and trans ferred were similar among the groups. The implantation and clinical pregnan cy rates were also comparable. Conclusion: The presence and extent of endom etriosis do not affect implantation and clinical pregnancy rates in patient s undergoing ICSI. (C) 2001 Elsevier Science Ireland Ltd. All rights reserv ed.