Multicenter retrospective analysis of various primary pediatric malignant hepatic tumors - Management in a series of 47 Polish patients (1985-1995)

Forty-seven children treated in various Polish centers between 1985 and 199 5 for primary malignant liver tumors were retrospectively analyzed. Hepatob lastoma (HB) prevailed - it was Found in 39 cases. There were 6 hepatocarci noma (HCC) cases and 2 cases of undifferentiated sarcoma (UDS). In 44% of H E patients the tumor involved both liver lobes. 18% of children with HE pre sented with pulmonary metastases at diagnosis. Chemotherapy was applied in 92% of cases (preoperatively in 67%). Tumor resection was performed in 56% of He patients. Overall survival of patients with hepatoblastoma was 43.6%, while it was 50% for hepatocarcinoma and 100% for undifferentiated sarcoma IZ cases only). Mean observation time was 58 months. The hepatoblastoma su bgroup, being the largest (83% of all cases), was analyzed separately for p rognostic factors. Completeness of tumor excision strongly influenced survi val. involvement of both lobes of the liver and multifocality of the tumor were other adverse prognostic factors.