ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure

Authors
Doggrell, SA
Citation
Sa. Doggrell, ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure, EXPERT OP I, 10(5), 2001, pp. 981-983
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERT OPINION ON INVESTIGATIONAL DRUGS
ISSN journal
13543784 → ACNP
Volume
10
Issue
5
Year of publication
2001
Pages
981 - 983
Database
ISI
SICI code
1354-3784(200105)10:5<981:ADCSAH>2.0.ZU;2-M
Abstract
Vascular and/or myocardial stiffness is a major problem in ageing, diabetes , hypertension and heart failure. The development of the stiffness is partl y due to the formation of glucose-dependent cross-links in the collagen. AL T-711 cleaves these cross-links. In aged-rhesus monkeys, ALT-711 decreases vascular stiffness and this effect is reversible. ALT-711 also decreases my ocardial stiffness in the monkeys bur this effect is not reversible in 39 w eeks. ALT-711 has potential in the treatment of the stiffness associated wi th diabetes, hypertension and heart failure.