Impact of different therapeutic regimens on the outcome of patients with Crohn's disease of the upper gastrointestinal tract

Background: To follow-up clinical and biochemical features in patients with Crohn's disease (CD) of the upper gastrointestinal (GI) tract and to evalu ate the impact of different therapeutics on the outcome of these patients. Methods: 32 CD patients with endoscopically and histologically proven CD of the upper GI tract were included into this retrospective study. Gastroduod enal and intestinal permeability rests, inflammatory parameters, Crohn's Di sease Activity Index (CDAI), and upper gastrointestinal complaint profile w ere sequentially assessed. These parameters were assessed at the beginning and followed up during therapies with antisecretory drugs, mesalamine, pred nisolone, and azathioprine. Results: Symptoms responded to antisecretory dr ugs. Gastroduodenal permeability increased under mesalamine. Gastroduodenal and intestinal permeability as well as CDAI decreased under prednisolone. Under azathioprine, gastroduodenal and intestinal permeability. CDAI, and C -reactive protein decreased.