Modeling the active site chemistry of liver alcohol dehydrogenase: Mononuclear zinc methanol and N,N-Dimethylformamide complexes of a nitrogen/sulfurligand possessing an internal hydrogen bond donor

Authors
Berreau, LM Makowska-Grzyska, MM Arif, AM
Citation
Lm. Berreau et al., Modeling the active site chemistry of liver alcohol dehydrogenase: Mononuclear zinc methanol and N,N-Dimethylformamide complexes of a nitrogen/sulfurligand possessing an internal hydrogen bond donor, INORG CHEM, 40(10), 2001, pp. 2212
Citations number
29
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
40
Issue
10
Year of publication
2001
Database
ISI
SICI code
0020-1669(20010507)40:10<2212:MTASCO>2.0.ZU;2-4
Abstract
Using a novel nitrogen/sulfur ligand possessing a single internal hydrogen bond donor (bmapa, N,N-bis-(2-methylthio)ethyl-N-(6-amino-2-pyridylmethyl)- amine), mononuclear zinc complexes possessing a single zinc-bound methanol ([(bmapa)Zn(MeOH)]-(ClO4)(2) . MeOH, 1 . MeOH) or N,N-dimethylformamide ([ (bmapa)Zn(DMF)](ClO4)(2), 2) molecule have been synthesized and structurall y characterized. These complexes are structurally relevant to substrate- an d inhibitor-bound forms of liver alcohol dehydrogenase (LADH) and exhibit h ydrogen-bonding interactions akin to those found in the active site of LADH .