Development of novel water-soluble, organometallic compounds for potentialuse in nuclear medicine: Synthesis, characterization, and H-1 and P-31 NMRinvestigations of the complexes fac-[ReBr(CO)(3)L] (L = bis(bis(hydroxymethyl)phosphino)ethane, bis(bis(hydroxymethyl)phosphino)benzene)

Citation
R. Schibli et al., Development of novel water-soluble, organometallic compounds for potentialuse in nuclear medicine: Synthesis, characterization, and H-1 and P-31 NMRinvestigations of the complexes fac-[ReBr(CO)(3)L] (L = bis(bis(hydroxymethyl)phosphino)ethane, bis(bis(hydroxymethyl)phosphino)benzene), INORG CHEM, 40(10), 2001, pp. 2358-2362
Citations number
31
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
40
Issue
10
Year of publication
2001
Pages
2358 - 2362
Database
ISI
SICI code
0020-1669(20010507)40:10<2358:DONWOC>2.0.ZU;2-8
Abstract
The bidentate, water-soluble phosphine ligands, bis(bis(hydroxymethyl)phosp hino)benzene (HMPB, 1) and bis(bis(hydroxymethyl)phosphino)ethane (HMPE, 2) were reacted with the organometallic precursor fac-[ReBr3- (CO)(3)](2-), 3 , to produce the complexes fac-[Re(OH2)(CO)(3)L](+) and fac-[ReBr(CO)(3)L] (L = HMPE, HMPB), respectively, in good yields. The rhenium complexes fac-[ ReBr(CO)(3)HMPB], 5, and fac-[R3Br(CO)(3)HMPE], 8, were characterized using H-1 and P-31 NMR spectroscopy. The structure of fac-[ReBr(CO)(3)HMPB] was confirmed by single-crystal X-ray spectroscopy. The substitution reactions of HMPE/HMPB with the rhenium precursor 3 in aqueous solution were monitore d using time-dependent P-31 NMR techniques. A significant discrepancy in th e reaction kinetics and the substitution mechanism between the two bidentat e ligands could be observed presumably due to the different chemical backbo nes.