NOVEL NONNUCLEOSIDE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1REVERSE-TRANSCRIPTASE .6. 2-INDOL-3-YL-DIPYRIDODIAZEPINONE AND 2-AZAINDOL-3-YL-DIPYRIDODIAZEPINONE

Authors
KELLY TA MCNEIL DW ROSE JM DAVID E SHIH CK GROB PM
Citation
Ta. Kelly et al., NOVEL NONNUCLEOSIDE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1REVERSE-TRANSCRIPTASE .6. 2-INDOL-3-YL-DIPYRIDODIAZEPINONE AND 2-AZAINDOL-3-YL-DIPYRIDODIAZEPINONE, Journal of medicinal chemistry, 40(15), 1997, pp. 2430-2433
Citations number
19
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
40
Issue
15
Year of publication
1997
Pages
2430 - 2433
Database
ISI
SICI code
0022-2623(1997)40:15<2430:NNIOHT>2.0.ZU;2-D
Abstract
Modification of the non-nucleoside inhibitor of HIV-1 reverse transcri ptase nevirapine (Viramune) by incorporation of a 2-indolyl substituen t confers activity against several mutant forms of the enzyme.