Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis

Citation
N. Mickels et al., Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis, J CLIN PER, 28(5), 2001, pp. 404-410
Citations number
29
Categorie Soggetti
Dentistry/Oral Surgery & Medicine","da verificare
Journal title
JOURNAL OF CLINICAL PERIODONTOLOGY
ISSN journal
03036979 → ACNP
Volume
28
Issue
5
Year of publication
2001
Pages
404 - 410
Database
ISI
SICI code
0303-6979(200105)28:5<404:CAMEOA>2.0.ZU;2-5
Abstract
Objective: P-113, a 12 amino acid histatin-based peptide, was evaluated in a mouthrinse formulation for safety prevention of the development of experi mental gingivitis, and for its effects on periodontal flora. Method: 159 periodontally healthy subjects abstained from oral hygiene proc edures and self-administered either 0.005%, 0.01%, 0.05% P-113 or placebo m outhrinse formulations twice daily over a four week treatment period. Durin g this time, the safety, anti-plaque, and anti-gingivitis effects of P-113 were evaluated. Results: There was a significant reduction in plaque (p = 0.046) and a redu ction in gingivitis (p = 0.086) for subjects using 0.01% P-113 mouthrinse. Significantly more subjects in the 0.01% and 0.05% treatment groups showed a small increase in plaque index of <0.25 as compared to the placebo group (p < 0.05). Similar trends were noted for changes in the % of sites with bl eeding on probing in the 0.01% P-113 group. There were no treatment-related adverse events, and there were no adverse shifts in supragingival microflo ra during the study. Conclusion: These data suggest that P-113 mouthrinse is safe and reduces pl aque, gingivitis and gingival bleeding in the human experimental gingivitis model.