Cardiac and intestinal amyloidosis in a renal transplant recipient with familial Mediterranean fever

In Turkey, familial Mediterranean fever (FMF) is an important cause of neph rotic syndrome and endstage renal disease due to renal deposition of AA typ e amyloid, We report a case of living-related donor renal transplant recipi ent with FMF and renal AA type amyloidosis, who died of progressive heart f ailure due to cardiac involvement. The patient also had intractable diarrhe a caused by biopsy-proven intestinal amyloidosis, The patient was on 1 mg/d ay colchicine, Although he was attack-free throughout the post-transplant p eriod, intestinal and clinically significant cardiac amyloidosis, which imp lied the presence of sustained inflammation and continuing amyloid depositi on, appeared three years after renal transplantation. Cardiac deposition of AA amyloid may cause clinically significant heart dis ease, leading to cardiovascular mortality after renal transplantation for e nd-stage renal disease in FMF patients.