Hl. Woodcock et al., The almost bottleable triplet carbene: 2,6-dibromo-4-tert-butyl-2 ',6 '-bis(trifluoromethyl)-4 '-isopropyldiphenylcarbene, J AM CHEM S, 123(18), 2001, pp. 4331-4335
Computations on 2,6-dibromo-4-tert-butyl-2',6'-bis(trifluoromethyl)-4'-isop
ropyldiphenylcarbene ( 1) using ab initio and density functional theory met
hods underscore the unusual stability of the tripler over the singlet state
. At the B3LYP/6-311G(d,p) level. the triplet state had a slightly bent cen
tral C-C-C bond angle of 167 degrees, whereas this angle in the singlet was
134 degrees. The B3LYP singlet-triplet splitting (12.2 kcal/mol) was large
r than that of the parent molecule (5.8 kcal/mol), diphenylcarbene (2), whi
ch also has a triplet ground state. The energy of a suitable isodesmic reac
tion showed the triplet and singlet states of 1 to be destabilized, by 6.3
and 12.5 kcal/mol. respectively, due to the combined effects of the CF3, Br
, and alkyl substituents. The linear-coplanar form of (3)1, which might fac
ilitate dimerization or electrophilic attack ar the more exposed diradical
center, was prohibitively (35.9 kcal/mol) higher in energy. Our results con
firm Tomioka's conclusion that the triplet diarylcarbene, ortho-substituted
with bulky CF3 and Br substituents, is persistent due to steric protection
of the diradical center. Dimerization and other possible reaction pathways
are inhibited, not only by the bulky ortho substituents but also by the Fa
ra alkyl groups. The increase in stability of the triplet ((3)1) state rela
tive to the singlet((1)1) state does not influence the reactivity directly.