Exploration of an efficient method for optical resolution of etodolac

Authors
Chou, SY Tseng, CL Chang, LS
Citation
Sy. Chou et al., Exploration of an efficient method for optical resolution of etodolac, J CHIN CHEM, 48(2), 2001, pp. 229-234
Citations number
13
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
48
Issue
2
Year of publication
2001
Pages
229 - 234
Database
ISI
SICI code
0009-4536(200104)48:2<229:EOAEMF>2.0.ZU;2-4
Abstract
The exploration of an efficient method for resolving etodolac using either L-cinchonidinium salt or chiral isopinocamphenol diastereomeric esters is d escribed herein. Furthermore, racemization mechanism of chiral etodolac is rationalized in terms of an isotope labeling experiment.