Carprofen in the aqueous humor of dogs and cats with uveitis

To show the antiphlogistic effect of carprofen in the eye, pharmacokinetic and pharmacodynamic properties of carprofen were examined in paired aqueous and serum samples of 150 eyes of dogs and 52 eyes of cats with or without clinical signs of uveitis. After intravenous application (4,4 mg/kg KGW) carprofen was found in almost every sample collected from healthy and inflamed eyes of dogs and cats aft er 40 minutes. With increasing severity of uveitis the concentration of pro tein and carprofen also increased which might be explained by the high prot ein-binding property of this NSAID. Based on the ophthalmologic examination the patients with uveitis were furt her grouped in animals with mild, lens-induced uveitis and animals with sev ere uveitis. The severity of the uveitis was evaluated by the concentration of protein and prostaglandin E-2 in the aqueous humor. In dogs and cats th e aqueous concentrations of protein and PGE(2) in healthy eyes was signific ant lower than in eyes with severe uveitis. However in eyes with mild uveit is the concentration of both parameters was not significantly higher than i n the eyes without uveitis. There was no difference in the concentration of protein or prostaglandin E- 2 in the aqueous humor of the dogs and cats receiving carprofen or untreate d.