Mutual effect of the interaction of human serum albumin with cellulose in water

Adsorption of human serum albumin to microcrystalline cellulose interface h as been determined as functions of protein concentration and pH of the aque ous solutions. The maximum adsorption value is reached at the protein isoel ectric point. The study of adsorption at several values of pH indicates tha t its interaction with the MCC interface is not controlled by the electrost atic effect. The FTIR, C-13 NMR data reveal that human serum albumin denatu rates at its IEP and its macromolecules become extended. Resulting intercal ates consist of microcrystalline cellulose, albumin, and solvent.