Expression of the Na-K-2Cl-cotransporter NKCC1 during mouse development

Here we describe the expression pattern of the Na-K-2Cl-cotransporter NKKC1 during embryonal and early postnatal mouse development. During early stage s hybridization signals were detected over single cells of the developing n euroepithelia, whereas the neuroepithelium of the basal telencephalon was l abeled continuously. With ongoing differentiation a distinct pattern of hyb ridization became apparent, which switched from a neuronal to a more glial pattern in the adult. Outside the nervous system NKCC1 transcripts were pre sent in many organs and were mostly confined to epithelia. (C) 2001 Elsevie r Science Ireland Ltd. All rights reserved.