Induction of alpha 1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell

Authors
Lee, SY Lim, JW Kim, YM Lee, IH Choi, YC Park, KC
Citation
Sy. Lee et al., Induction of alpha 1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell, MOL CELLS, 11(2), 2001, pp. 164-169
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
MOLECULES AND CELLS
ISSN journal
10168478 → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
164 - 169
Database
ISI
SICI code
1016-8478(20010430)11:2<164:IOA1GM>2.0.ZU;2-D
Abstract
The mRNA for the alpha1-acid glycoprotein (AAG) was expressed not only in h epatoma cells, but also in non-hepatic cancel cells, The expression of the AAG mRNA in HT-29 human colon carcinoma cells is induced by cytokines, IL-6 , IL-1, and TNF-alpha, in a manner characteristic of the acute phase respon se, and the expression of AAG mRNA was up-regulated in differentiated HT-29 cells.