Monomelic amyotrophy with late progression

Monomelic amyotrophy is a sporadic juvenile-onset disease that presents wit h gradual onset of weakness and atrophy in the hand muscles unilaterally. G enerally, this disease is considered a 'benign' and non-progressive motor n euron disease, which stabilizes within five years of onset. We discuss a ca se that illustrates that monomelic amyotrophy may rarely exhibit late clini cal progression to the lower extremities after a prolonged period of diseas e stability. (C) 2001 Elsevier Science B.V. All rights reserved.