Various types of tubes for long have been used experimentally to study mech
anisms of nerve regeneration. Recently, silicone tubes have been used succe
ssfully to repair human ulnar and median nerves. Tubes may be interesting a
lternatives to conventional nerve sutures for reconstruction of segmental d
efects between nerve ends and for treatment of painful neuromas. Manipulati
on of additive cells, factors, and matrices with modern molecular technique
s are exciting areas of future research.