Defining a role for the inhibitors of apoptosis proteins in prostate cancer

Authors
McEleny, KR Watson, RWG Fitzpatrick, JM
Citation
Kr. Mceleny et al., Defining a role for the inhibitors of apoptosis proteins in prostate cancer, PROSTATE C, 4(1), 2001, pp. 28-32
Citations number
64
Categorie Soggetti
Urology & Nephrology
Journal title
PROSTATE CANCER AND PROSTATIC DISEASES
ISSN journal
13657852 → ACNP
Volume
4
Issue
1
Year of publication
2001
Pages
28 - 32
Database
ISI
SICI code
1365-7852(2001)4:1<28:DARFTI>2.0.ZU;2-B
Abstract
The aim of this paper is to review the inhibitors of apoptosis proteins, a recently discovered group of caspase inhibitors. We will briefly review the relevance of apoptosis in prostate cancer and some of the control mechanis ms, before describing the structure, function and regulation of these molec ules. Lastly, we will consider the evidence for the role that IAPs may have in cancer and the implications for prostate cancer in particular.