Two convenient and simple methods for the synthesis of 1,3-disubstituted na
phtho[2,3-c]pyran-5, IO-diones, which involve the introduction of acylmethy
l groups onto 2-(l-hydroxyethyl)-1,4-naphthoquinones and subsequent base- a
nd acid-induced ring closure, were developed. (C) 2001 Elsevier Science Ltd
. All rights reserved.