Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones

Authors
Lee, HK Chun, JS Pak, CS
Citation
Hk. Lee et al., Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones, TETRAHEDR L, 42(20), 2001, pp. 3483-3486
Citations number
39
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
20
Year of publication
2001
Pages
3483 - 3486
Database
ISI
SICI code
0040-4039(20010514)42:20<3483:FTO32T>2.0.ZU;2-C
Abstract
Chiral 5,6-disubstituted-5,6-dihydro-2(1H)-pyridones were prepared efficien tly from readily accessible 3,4-disubstituted-2-azetidinones having preadju sted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and re-cyclization to 2-pyridones. (C) 2001 Elsevier Science Ltd. All rights re served.