Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

Authors
Takada, N Umemura, N Suenaga, K Chou, T Nagatsu, A Haino, T Yamada, K Uemura, D
Citation
N. Takada et al., Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata, TETRAHEDR L, 42(20), 2001, pp. 3491-3494
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
20
Year of publication
2001
Pages
3491 - 3494
Database
ISI
SICI code
0040-4039(20010514)42:20<3491:PBACTM>2.0.ZU;2-#
Abstract
Pinnatoxins B and C, the most toxic components in the pinnatoxin series, we re successfully purified from the Okinawan bivalve Pinna muricata. Their gr oss structures were determined based on NMR and MS/MS spectral analyses. Th eir stereostructures were mainly determined by transformation reactions. Pi nnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycl e composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the sa me as in pinnatoxins A and D. (C) 2001 Elsevier Science Ltd. All rights res erved.