A convenient synthesis of N-Fmoc-N,N '-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N '-bis-Boc-7-guanyl-Tic-OH, GTIC)

Authors
Santagada, V Fiorino, F Severino, B Salvadori, S Lazarus, LH Bryant, SD Caliendo, G
Citation
V. Santagada et al., A convenient synthesis of N-Fmoc-N,N '-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N '-bis-Boc-7-guanyl-Tic-OH, GTIC), TETRAHEDR L, 42(20), 2001, pp. 3507-3509
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
20
Year of publication
2001
Pages
3507 - 3509
Database
ISI
SICI code
0040-4039(20010514)42:20<3507:ACSON'>2.0.ZU;2-C
Abstract
Fmoc-N,N'-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained am ino acid with basic properties, has been synthesized in four steps. This am ino acid can be incorporated into peptides using standard Fmoc solid phase synthesis, and to test its potential for biological activity applications, we prepared an analog of H-Dmt-Tic-NH2. (C) 2001 Elsevier Science Ltd. All rights reserved.