Kidney transplantation during the first trimester of pregnancy: Immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone

We present a case of living, related-donor kidney transplantation during th e first trimester of pregnancy. The patient received mycophenolate mofetil (MMF), tacrolimus, and prednisone throughout the entire pregnancy. This is the first reported case of use of MMF during pregnancy. The mother did well , except for mild preeclampsia and mild renal insufficiency at term. The ba by girl was born prematurely at week 35 3/7. The only possible teratogenic effects detected included hypoplastic nails and short fifth fingers. No chr omosomal abnormalities were found. The child is growing and developing norm ally. Although we do not recommend the use of mycophenolate mofetil during pregnancy based on this experience, it is reassuring to know that a success ful outcome can be expected in mothers treated with MMF during pregnancy.