One hundred and six years ago, the surgeon Ludwig Rehn from Frankfurt am Ma
in held a pioneering lecture in Berlin about the possible origins of bladde
r tumours. He thereby gave the decisive impulse for cancer research in gene
ral and specifically for the investigation of aetiological factors involved
in the development of urogenital tract tumours. Thereafter, this resulted
in an intensified scientific discussion addressing this issue. Although the
detailed evaluation of the causes finally contributing to tumour growth is
still ongoing, the work of Ludwig Rehn on bladder tumours among aniline wo
rkers considerably promoted the establishment of urology as a specialised f
ield within German clinical medicine and is therefore a milestone in the hi
story of medicine.