Opto-thermal measurement of barrier cream residence time on skin in-vivo

Authors
Guo, XX Ciortea, LI Chilcott, RP Imhof, RE Xiao, P
Citation
Xx. Guo et al., Opto-thermal measurement of barrier cream residence time on skin in-vivo, ANAL SCI, 17, 2001, pp. S346-S348
Citations number
8
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL SCIENCES
ISSN journal
09106340 → ACNP
Volume
17
Year of publication
2001
Pages
S346 - S348
Database
ISI
SICI code
0910-6340(2001)17:<S346:OMOBCR>2.0.ZU;2-C
Abstract
We report the non-invasive opto-thermal measurement of the residence time o f a barrier cream on in-vivo skin. These measurements revealed an approxima tely exponential decrease of cream layer thickness with a 1/e disappearance time of similar to 60 minutes. Measurements on a cream layer on a polymer substrate under otherwise similar conditions confirmed that penetration int o the stratum corneum, rather than abrasion or evaporative loss, was the ma in cause of the observed disappearance.