Injectable medication for the treatment of multiple sclerosis: The influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject

The management of many, chronic illnesses involves medications that must be injected on a frequent basis. With fewer support resources available, pati ents are increasingly being obliged to manage injectable medications themse lves. Interferon beta-1a (IFN beta -1a), recommended for the treatment of m ultiple sclerosis (MS), must be injected intramuscularly on a weekly basis. Patients are generally advised and taught to self-inject, if possible. Thi s longitudinal study examined cognitive and affective contributions to the ability to self-inject and adherence to IFN beta -1a over 6 months followin g initiation of medication. Participants were 101 patients with a relapsing form of MS. Injection self-efficacy expectations, injection anxiety, adher ence expectations, method of injection administration, and 6-month adherenc e to IFN beta -1a were fitted to a path analytic model. Pretreatment inject ion self-efficacy expectations were significantly related to 6-month adhere nce. This relation was mediated by the patient's ability to self-inject. Pa tients 'experienced level of injection anxiety was related to adherence bur not to method of injection.