SYNTHESIS AND ENZYMATIC STABILITY OF OLIGONUCLEOTIDE INCORPORATED WITH ISONUCLEOSIDE

Authors
YU HW ZHANG LAR MA LT ZHANG LH
Citation
Hw. Yu et al., SYNTHESIS AND ENZYMATIC STABILITY OF OLIGONUCLEOTIDE INCORPORATED WITH ISONUCLEOSIDE, Gaodeng xuexiao huaxue xuebao, 18(7), 1997, pp. 1103-1106
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
18
Issue
7
Year of publication
1997
Pages
1103 - 1106
Database
ISI
SICI code
0251-0790(1997)18:7<1103:SAESOO>2.0.ZU;2-Y
Abstract
Two trideoxynucleotides incorporated with -(thymin-1-yl)-4'-(R)-hydrox y-5'-(S)-hydroxymethyl tetrahydrofuran in the 3' end (3) or in center (4) were synthesized via phosphotriester method in solution. Compounds 3 and 4 are stable towards Nuclease S1 compared with the normal tride oxynucleotides (2).