SYNTHESES OF POLY(PHOSPHATE-URETHANE)S AS DRUG-RELEASE MATERIALS

New biodegradable and biocompatible copolymers poly (phosphate-urethan e)a with elevated molecular weight were synthesized by the polycondens ation of Ser-Tyr or Tyr-Tyr dipeptide and phosphorodichloridate and fo llowed by reacting with 1,4-butane-di-isocyanate, The chemical structu res were confirmed by H-1 NMR, FTIR and elemental analysis, The molecu lar weight, and thermostability of these polymers were investigated, T he in vitro degradation and bovine serum albumin(BSA) release profile were also studied, It was found that the degradation rate of the mater ials and BSA release behavior can be modulated by varying the hydrohob ic properties of these poly (phosphate-urethane)s.