Dust depletion plays a key role in understanding the nature of Damped Lyman
or systems (DLAs). In this paper we point out a previously unnoticed antic
orrelation between the observed abundance ratio [X/Zn] (where Zn is assumed
to be undepleted and X stands for the refractories Fe, Cr and Ni) and meta
l column density ([Zn/H] + log(N-HI)) in DLAs. We suggest that this trend i
s an unambiguous sign of dust depletion, since metal column density is a me
asure of the amount of dust along the line of sight. Assuming that DLAs are
(proto-) galactic disks and using detailed chemical evolution models with
metallicity dependent yields we study chemical evolution and dust depletion
patterns for ct and iron-peak elements in DLAs. When observational constra
ints on the metal column density of DLAs are taken into account las suggest
ed in Boisse et al. 1998) we find that our models reproduce fairly well the
observed mild redshift evolution of the abundances of 8 elements (Al, Si,
S, Cr, Mn, Fe, Zn and Ni) as well as the observed scatter at a given redshi
ft. By considering the aforementioned dependence of abundance ratios on met
al column density, we further explore the general dust depletion pattern in
DLAs, comparing to our model results and to a solar reference pattern. We
find that for low metal column densities (no depletion), our models compare
fairly well to the data, while a solar pattern has difficulties with Mn. A
t high metal column densities (amount of depletion similar to0.5 dex), the
solar pattern describes the data quite well, while our models have difficul
ties with S. We suggest that further measurements of those key elements, i.
e. Zn, S and Mn, will help us to gain more insight into tile nature of DLAs
. The presently uncertain nucleosynthesis of Zn in massive stars Ion which
a large part of these conclusions is based) should be carefully scrutinised
.