CYTOTOXICITY OF COPPER-COMPLEXES OF 2-FURALDEHYDE OXIME DERIVATIVES IN MURINE AND HUMAN TISSUE-CULTURED CELL-LINES

The copper complexes of fur an oxime derivatives were found to be pote nt cytotoxic agents in both murine and human tissue cultured cell line s which were either suspended or solid tumors. The ED50 values were fr equently improved over the clinically useful antineoplastic agents. Th ese copper complexes of 2-furaldehyde oximes were effective inhibitors of L1210 lymphoid leukemia DNA synthesis followed by RNA synthesis. P urine synthesis regulatory enzyme activities were markedly reduced by the compounds with marginal inhibition of t-RNA polymerase, and nucleo side kinases activities. L1210 DNA topoisomerase II activity was marke dly reduced with IC50 values better than the standard VP-26, etoposide . Yet, the copper complexes caused no further protein linked breaks th an VP-16 did, but did block phosphorylation activation of the topoisom erase II enzyme.