Interaction of N-myristoyldimyristoylphosphatidylethanolamine with dimyristoylphosphatidylcholine investigated by differential scanning calorimetry: binary phase diagram

The temperature-composition phase diagram was derived for hydrated, binary mixtures of N-mynstoyldimyristoylphosphatidylethanolamine (N-14 DMPE) and d imyristoylphosphatidylcholine by high sensitivity differential scanning cal orimetry. Gel phase immiscibility was detected In mixtures containing up to 20 mol% N-14 DMPE and there a as no evidence for compound formation betwee n the two components. In the fluid phase nearly complete miscibility is ind icated by the calorimetric data. These results are relevant to understandin g the role of N-acylphosphatidylethanolamines in the stress combating respo nses of organisms and in their application to developing liposome-based dru g delivery systems. (C) 2001 Elsevier Science B.V. All rights reserved.