Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase

Authors
Van den Berge, DL De Ridder, M Verovski, VN Janssens, MY Monsaert, C Storme, GA
Citation
Dl. Van Den Berge et al., Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase, BR J CANC, 84(8), 2001, pp. 1122-1125
Citations number
16
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
84
Issue
8
Year of publication
2001
Pages
1122 - 1125
Database
ISI
SICI code
0007-0920(20010420)84:8<1122:CHMTCR>2.0.ZU;2-M
Abstract
Chronic hypoxia up-regulated the mRNA and protein expression of inducible n itric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IF N)-gamma and interleukin (IL)-1 beta. Low concentrations of cytokines (1 un it ml(-1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chron ic hypoxia may potentially be exploited to increase tumour cell radiorespon se through the cytokine-inducible iNOS pathway. (C) 2001 Cancer Research Ca mpaign.