N. Kato et al., FACILE AND EFFICIENT SYNTHESIS OF 7,10-DIHYDROXY-6H-PYRAZOLO[4,5,1-DE]ACRIDIN-6-ONE VIA HYPERVALENT IODINE OXIDATION, Synthesis, (6), 1997, pp. 625
An improved synthetic procedure for xy-2-methyl-6H-pyrazolo[4,5,1-de]a
cridin-6-one(4), an intermediate of a novel class of antitumor agents,
was developed. An effective introduction of a hydroxy group to the C1
0 of ydroxy-2-methyl-6H-pyrazolo[4,5,1-de]acridin-6-one (2b) was accom
plished in two steps via the oxidation of 2b to the corresponding quin
one using hypervalent iodine reagent in an acidic medium, followed by
reduction of the resulting quinone upon treatment with aqueous sodium
hydrosulfite.