Rapid senescence induced by overexpression of p53 in NIH3T3 cells

Authors
Hu, JC Lei, Y Hong, X Lu, ZG Zhai, ZH
Citation
Jc. Hu et al., Rapid senescence induced by overexpression of p53 in NIH3T3 cells, CHIN SCI B, 46(8), 2001, pp. 653
Citations number
18
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
46
Issue
8
Year of publication
2001
Database
ISI
SICI code
1001-6538(200104)46:8<653:RSIBOO>2.0.ZU;2-T
Abstract
An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene, It exhibited rapidly charac teristic morphological and biochemical alterations related to replicative s enescence when being cultured in 32 degreesC. We suggested that the overexp ression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.