F. Chigr et al., Allosteric modulation of the GABA(A) receptor in rat hypothalamus by somatostatin is altered by stress, CLIN EXP PH, 28(4), 2001, pp. 329-330
Citations number
5
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
1. This autoradiographic study was conducted to investigate somatostatin mo
dulation of GABA(A) receptor binding in hypothalamic structures of immobili
zation-stressed rats.
2. GABA(A) receptor binding was labelled with [S-35]-t-butylbicyclophosphor
othionate (TBPS), which binds in or near the chloride channel.
3. Several structures of the rat hypothalamus (i.e. the peri- and paraventr
icular nuclei) display an increase in [S-35]-TBPS binding as well as an alt
eration of the modulatory effect of somatostatin on the GABA(A) receptor co
mplex under stress. Furthermore, these results demonstrate for the first ti
me that somatostatin is particularly effective in modifying [S-35]-TBPS bin
ding to the GABA(A) receptor in rat hypothalamus.