Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase

This paper aimed to investigate the effect of lumbrokinase on the anticoagu lation and fibrinolysis in treating cerebral infarction. Lumbrokinase was u sed in patients with cerebral infarction. Patients were randomly divided in to treatment group (n = 31) and control group (n = 20). Single blind method was used in this investigation. The Chinese stroke score was used to evalu ate the results of treatment before and after administration of lumbrokinas e. Kaolin partial thromboplastin time (KPTT), prothrombin time (PT), fibrin ogen content, VWF content were analyzed, and tissue plasminogen activator ( t-PA) activity, plasminogen activator inhibitor (PAI) activity, D-dimer lev el were assayed. In both groups, the stroke score decreased after administr ation, but in the treatment group, it was more obvious. In the treatment gr oup, KPTT was prolonged, t-PA activity and D-dimer level increased, while t he content of fibrinogen decreased significantly. There were no significant changes of PT and PAI activity in both groups. It is concluded that lumbro kinase is beneficial to the treatment of cerebral infarction. The effect of lumbrokinase is related to the inhibition of intrinsic coagulation pathway and the activation of fibrinolysis via an increase of t-PA activity.