Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy

We report the ease histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroida l anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral h ead avascular necrosis. This is a diagnosis that should be considered in pa tients with prostate cancer who present with hip pain in the absence of bio chemical evidence of disease progression.