An in vitro study of the activity of 10 oral agents against 153 pediatric i
solates of Streptococcus pneumoniae identified moxifloxacin and levofloxaci
n as the most active agents regardless of penicillin or macrolide susceptib
ility. Moxifloxacin inhibited all strains at 0.25 mug/ml and was 8- to 16-f
old more potent than levofloxacin. (C) 2001 Elsevier Science inc. All right
s reserved.