AVOIDANCE OF SULFUR LOSS DURING AMMONIA TREATMENT OF OLIGONUCLEOTIDE PHOSPHOROTHIOATES

Authors
REESE CB SONG QL
Citation
Cb. Reese et Ql. Song, AVOIDANCE OF SULFUR LOSS DURING AMMONIA TREATMENT OF OLIGONUCLEOTIDE PHOSPHOROTHIOATES, Nucleic acids research, 25(14), 1997, pp. 2943-2944
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleic acids research → ACNP
ISSN journal
03051048
Volume
25
Issue
14
Year of publication
1997
Pages
2943 - 2944
Database
ISI
SICI code
0305-1048(1997)25:14<2943:AOSLDA>2.0.ZU;2-L
Abstract
Sulfur loss during the unblocking of phosphorothioate analogues of oli gonucleotides with concentrated aqueous ammonia can be completely supp ressed by the addition of 2-mercaptoethanol.