We use a pseudodifferential calculus on differentiable groupoids to obtain
new analytical results on geometric operators on certain noncompact Riemann
ian manifolds. The first step is to establish that the geometric operators
belong to a pseudodifferential calculus on an associated differentiable gro
upoid. This then leads to Fredholmness criteria for geometric operators on
suitable noncompact manifolds, as well as to an inductive procedure to comp
ute their essential spectra. As an application, we answer a question of Mel
rose on the essential spectrum of the Laplace operator on manifolds with mu
lticylindrical ends.