The tripartite motif family identifies cell compartments

Authors
Reymond, A Meroni, G Fantozzi, A Merla, G Cairo, S Luzi, L Riganelli, D Zanaria, E Messali, S Cainarca, S Guffanti, A Minucci, S Pelicci, PG Ballabio, A
Citation
A. Reymond et al., The tripartite motif family identifies cell compartments, EMBO J, 20(9), 2001, pp. 2140-2151
Citations number
64
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EMBO JOURNAL
ISSN journal
02614189 → ACNP
Volume
20
Issue
9
Year of publication
2001
Pages
2140 - 2151
Database
ISI
SICI code
0261-4189(20010501)20:9<2140:TTMFIC>2.0.ZU;2-Z
Abstract
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM), A total of 37 TRIM genes/proteins were studied, 21 of which were novel. Th e results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.