Semipreparative scale enantioseparation of racemic amine and amino ester hydrogen perchlorate salts using a silica gel-bound optically active di-tert-butylpyridino-18-crown-6 ligand
Z. Kontos et al., Semipreparative scale enantioseparation of racemic amine and amino ester hydrogen perchlorate salts using a silica gel-bound optically active di-tert-butylpyridino-18-crown-6 ligand, ENANTIOMER, 5(6), 2000, pp. 561-566
We report herein results on the enantioseparation of selected racemic amine
and amino ester hydrogen perchlorate salts using a silica gel-bound optica
lly pure chiral di-tert-butylpyridino-18-crown-6 ligand (R,R)-1. The effect
of solvent composition was studied using appropriate binary and ternary so
lvent mixtures as eluents. We found that acetonitrile/ methanol/ dichlorome
thane (MeCN/MeOH/CH2Cl2) ternary solvent mixtures gave better enantiosepara
tions for the racemic salts using chiral stationary phase (R,R)-1 than any
of the binary ones. In the present paper we also describe the studies of ch
romatographic parameters such as loading, flow rate and eluent polarity.