Valacyclovir in the treatment of primoinfection due to genital herpesvirus: comparative study

BASES. To know the therapeutic efficiency in the genital herpes of two drug s: acyclovir and valaciclovir. METHODS. There were included in the study 142 patients with diagnostic of c linic first episode by genital herpes in two equal groups of 71 patients ea ch one. The distribution in both groups was random to receive one of the fo llowing treatment standards: acyclovir 200 mg by verbal each 5 hours, durin g 7 days; valaciclovir: 500 mg by verbal each 12 hours during 7 days being valued objetive and subjetive response to the treatment. RESULTS. The prevailing sympton was the pain (45% and 46.4%), followed by t he warmth or burning sensation. The most frecuent injury in both groups wer e the bladdres (39.4% and 46.4%). The analysis response to the treatment in relationship to the symptons as well as in the injuries it could be apreci ated that there are not significant differences in the patients treated in both groups (p=0,3). The adverse effect comunicated by the discussed patien ts were scarce and similar in both groups. CONCLUSIONS. Both drugs are suitable for the treatment of the genital herpe s. The adavantage abserved with the valaciclovir is the dosing comfort and the facility of complimenting the treatment.